The present study aimed to determine concentrations of sodium, potassium, copper and zinc in milk and blood plasma of Awassi, Baladi ewes and Boer, Baladi goats during the winter and summer seasons. Used in this experiment number of 180 ewes and goats. The blood and milk samples were taken after one month post partum. The samples were stored at -18 ºC till time of analysis. The minerals were determined by Atomic Absorption Spectrophotometer used to estimate copper and zinc and Flame Emission Photometry was used for estimation of sodium and potassium. The overall concentrations of (sodium, potassium, copper and zinc) in milk of Awassi and Baladi ewes were (533.8 ± 13.3, 493.9 ± 13.0, 1475.0 ± 20.4, 1372.6± 26.3, 0.740 ± 0.15, 0.442± 0.20, 6.8 ± 0.7 and 5.4± 0.6 mg/l), while in blood plasma were (2321.5± 10.8,  2034.3± 8.8, 186.2± 1.1, 142.5± 2.3, 0.87±0.01, 0.51±0.02, 1.72± 0.01 and 0.56± 0.02 mg/l) respectively. Meanwhile, concentrations of sodium, potassium, copper and zinc in milk of Boer and Baladi goats were (541.0 ± 15.6, 455.6 ± 14.3, 1660.3 ± 19.5, 1511.5 ± 13.9, 0.718 ± 0.25, 0.426± 0.30, 3.2 ± 0.3 and 2.7± 0.3 mg/l), while in blood plasma were (3263.7± 11.3, 1885.8± 11.3, 203.05± 1.7, 161.6± 1.6, 0.89±0.01, 0.55±0.01, 1.1± 0.01 and 0.51± 0.01 mg/l) respectively. The present results display that concentrations of sodium, potassium, copper and zinc in milk and blood plasma were higher in Awassi ewes and Boer goats compared with Baladi ewes and goats. Concentrations of studied elements in milk and blood plasma during the summer season recorded lower levels than winter season in ewes and goats. Thus, the study recommended supplementation of mixture of salts to diet of animals during the summer season in order to conservation of the minerals concentration in the normal levels in milk or blood. In addition, the assay of the studied minerals (sodium, potassium, copper and zinc) in milk compared with blood plasma is more easy and also accurate in ewes and goats.