The present study  was conducted to elucidate the relationship between humoral  immune response selection and some productive traits in three lines of  Fayoumi  cocks .A total of 300 male Fayoumi chicks were divided into three lines , control , high and low according to their immune response against SRBC injection . They were fed the formulated diets in adlibitum . Resutts showed that  the high line males ND,H9 had significantly higher immune response against NDV and H9 than the other lines . Thyroid  hormones concentration in  the control and low line were significantly higher than high line  . males but  non significant effect on T3/T4 ratio between all male lines  . The control line had better testosterone  hormone  level  than the high line,while. serum corticosterone hormone concentration was  higher in the control and high lines than the low line males . Ejaculate volume ,abnormal sperm percentage and total abnormal sperm / ejaculate did not significantly different between lines studied. the low line in sperm motility (score) was significantly higher than that from the high line. non significantly difference between the low line and the control . Sperm concentration, total sperm /ejaculate and total live sperm / ejaculate were significantly higher  in the low and control lines compared by the high line males . Both comb width , and  length , wattle width and length did not significantly  influenced by Fayoumi – selected lines . Serum total protein , albumin and globulin were significantly improved  for the high line followed by the control  line while the low line recorded the lowest value . both total cholesterol, triglycerides  , ASTand ALT did not significantly influenced by Fayoumi males selected lines . Avrage of immunoglobulins of different lines of Fayoumi males  after 10 days from injection of SRBC was significantly higher in the  high line males than the other line .  It is concluded  that the high line males had  significantly higher antibody titer against SRBC in terms of higher plasma IgG and IgM compared to males from the control and low line males .