The Aim of this work was finding out the relationship between haematological profile, glucose levels, cortisol and T3 hormones of Baladi and Shami kids and their mortality rate during the postnatal period under Sinai desert conditions. the present study was conducted at South-Sinai Research Station - Desert Research Center (DRC), Ras Sudr City, South Sinai Governorate, Egypt. Fifty pregnant does were randomly divided into two groups according to their breed Baladi and Shami 25 each group, Baladi does (averaged 21.12 kg LBW) while Shami does averaged 35.78 kg LBW, all animals were estrus synchronized using PGF2α during the Reproductive season from Sep to Feb 2016 and mated naturally. Gained kids were kept with their dams along the study period (Feb to Mar 2016). After parturition, 101 kids (39 and 62, Baladi and Shami, respectively) were observed for one month of age. The mortality percentages for male and female kids were respectively 33.33% and 14.28% in Baladi while were 87.50% and 36.84% in Shami. Throughout the post-partum period haematological profile, glucose, cortisol and T3 were recorded at intervals of 1 day, 7^th,14^th,21^th and 28^th for all kids. the blood serum was then separated and kept at -25 ° C until the analysis was performed. In general, statistical analysis showed, the haematological profile of kids showed, the overall mean of WBCs (x10³/µL), RBCs, (x10⁶/µL), Hb (g/dl) and Hct (%) in Baladi and Shami kids , were (6.81 and 7.71), (8.70 and 8.44), (9.99 and 9.91), and (30.31 and 29.72), respectively, without significant difference. The obtained results showed that overall mean of glucose levels in Baladi and Shami kids, were (76.99 and 53.74), respectively with significant difference (P<0.051). The overall mean of cortisol in Baladi and Shami kids, were (487.32 and 496.86), respectively without significant difference. While The overall mean of T3 hormone of Baladi and Shami kids, were (1.37 and 1.35), respectively with significant difference (P<0.051). Kids that died then after had lower values of all studied parameters. The percentages decrease as compared to live kids within the 14 days in WBCs was between 25% and 41% in Baladi kids, while in Shami kids was between 20% and 41%. For RBCs, the decreased was between 28% and 31% in Baladi while was between 21% and 29% in Shami kids. The percentage decrease of Hb in Baladi kids was between 27% and 35% while in Shami kids was between 23% and 34%. The percentage decrease of Ht in Baladi kids was between 12% and 22% while in Shami kids was between 8.1% and 23%. The decrease percentage of glucose levels in Baladi were between 39% and 47%, while in Shami kids, was between 21.3% and 28.5%. The cortisol hormone in Baladi kids were between 28% and 34%, while in Shami kids were 21%-31%. For T3 hormone the decrease was between 18.5% and 19.2% in Baladi while was between 14.8% and 19.1% in Shami kids.  it was concluded that Hematological profile, glucose, cortisol and T3 are indicative of health status of kids and had great effect on kids' survivability. Baladi kids had significant higher values of both glucose and T3 than Shami ones that might indicate its higher ability to cope cold stress hence showed significant reduction of mortality rate.