The current study was carried out at Kafr El-Sheikh Governorate during 2016 to investigate the effect of using three water quality; Nile water (Abou-Omar, W1), mixed Nile and polluted drainage water (El-Bana, W2) and polluted drainage water (Kafr Dokhmeis, W3) in irrigation of agricultural land on accumulation of Cd in clay soil and berseem grown thereon and subsequently in growth performance of rabbits  fed on diets contaminated with cadmium at same level of cadmium in this berseem. The role of Selenium (Se),Vitamin E (Vit. E), or Zinc (Zn) as antioxidants and as detoxifying against cadmium chloride (CdCl₂) was studied in 120 growing APRI rabbits. Rabbits were classified into six groups. Rabbits of the treatment 1(T1) served as diet as a control diet contained 0.10 mg cadmium (Cd) on DM basis. Treatment 2 (T2): Fed contaminated diet to provide final level of 0.96 mg Cd, Treatment (3):  Fed diet supplemented with cadmium chloride plus vitamin E (150 mg/kg diet). Treatment 4 (T4): Fed diet supplemented with cadmium chloride plus Se (0.2 mg/kg diet). Treatment5 (T5): Fed diet supplemented with cadmium chloride plus Zn (100 mg/kg diet) and Treatment6 (T6): Fed diet supplemented with cadmium chloride plus 150 mg vit E plus 0.2 mg Se plus 100 mg Zn /kg diet). The results showed that polluted drainage water (W3) recorded the highest concentrations of Cd followed by W2, while W1 had the lowest concentrations. Moreover, berseem samples grown in soil irrigated with W3 showed the highest Cd content followed by berseem grown in soil irrigated with W2, while berseem grown in soil irrigated with W1 had the lowest contents. Cadmium chloride treated group showed significantly a decrease in growth performance and nutrient digestibility while supplementation with vit. E , Se or Zn alone or in combination to the contaminated diet significantly improved all these growth parameters. In the contaminated diet with Cd (T2), many large disturbance occurred in all measured blood constituents, while supplementing vit E , Se or Zn alone or in combination to the same diet, significantly improved these blood constituents. Moreover, vitamin E, Se and Zn combination showed more efficacy than vit. E, Se or Zn alone.