The experimental study was managed to achieve the effect of heat stress on bodyweight, thermoregulatory and physiological responses of Baladi and Shami goats. Twenty adult female Baladi and Shami goats (10 of Baladi goats and 10 of Shami goats) were used for the study. The goats were exposed to three different times (T1, T2 & T3) of temperaturetreatment; T1, T2 in August and T3 in September, Baladi and Shami goats were divided into two exposed groups to solar radiation (n=10). The results showed thatT1 periods was significantly (P<0.05) increased in relative humidity, while T2 period was significantly (P<0.05) increasedin ambient temperature and temperature-humidity index. Bodyweight showed a significant (P<0.05) decrease at T3 in both breeds. Baladi goats showed a significant (P<0.05) increase at T2 compared to Shami goats in rectal and skin temperature, respiratory rate, white blood cells, albumin, serum ALT, and phosphorus. While Shami goats showed increase in coat and Ear temperatures, also, total protein, AST and CL at T1 compared with Baladi goats. It is accomplished that heat stress had a significant increaseeffect on body weight,thermoregulatory and physiological responses on Shami goats compared with Baladi goats.