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245484

EFFECT OF SELENIUM NANOPARTICLES AND/OR spirulina platensis ON GROWTH, HEMATOBIOCHEMICAL, ANTIOXIDANT STATUS, HORMONAL PROFILE, IMMUNITY, AND APOPTOSIS OF GROWING RABBITS EXPOSED TO THERMAL STRESS

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Last updated: 22 Jan 2023

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Abstract

This research was conducted to reconnoiter the influence of dietary supplementation of Spirulina platensis (SP) or/and selenium nanoparticles (SeNPs) on the growth, blood metabolites and antioxidants capacity of heat-stressed rabbits. Rabbits (n = 120) were divided into 4 experimental groups as the following: the 1st group fed basal diet without supplementation  and sarved as a control (CON). The 2nd group fed basal supplemented with 1 gm/kg diet of SP (SP), the 3rd group fed basal diet supplemented  with 50 mg/kg diet SeNPs (SeNPs) and 4th  group fed  basal diet supplemented with 1 gm/kg diet of SP (SP) plus50 mg/kg diet SeNPs (SeNPs) .
Dietary inclusion with SeNPs and SP significantly (P < 0.05) improved all growth indices in heat stressed rabbits. Circulating hemoglobin, platelets, total protein, albumin and globulins were significantly improved in SeNPs and SP+SeNPs groups compared with CON group; however, WBCs were significantly decreased in all treated groups. Significant reduction in ALT, total bilirubin, direct bilirubin, total glycerides, creatinine, and uric acids were observed in treated groups compared with the CON group.
 All experimental additives significantly improved the levels of IgG relative to CON group (P<0.001).
Dietary feed inclusion resulted in lower levels of oxidative stress (MDA and PCO; P < 0.001), while all treatments showed significant enhancement in the level of GSH.
The mixture of SP+SeNPs had higher level of T3 (P＜0.001), while both SP and SP+SeNPs treatments had lower values of plasma corticosterone (P＜0.001).
The morphologic of caspase3 immune expression of heat stressed rabbits presented moderate of intracytoplasmic immunoreactivity that existing by a substantial rise in part ratio of caspase 3 immunoreactivity related to another group.
Conclusively, the present results manifest that SeNPs and/or SP can be possibly to mitigate the negative influences of heat stressed rabbit by enhancing the antioxidant, immunological and reducing the apoptosis process.
 

Keywords

heat stress, Rabbit, growth indices, blood metabolites, antioxidant, apoptosis

Authors

First Name

Amr

Last Name

Bashar

MiddleName

-

Affiliation

Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Email

amrbashar@zu.edu.eg

City

Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Orcid

-

First Name

Sameh

Last Name

Abd el nour

MiddleName

-

Affiliation

Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Email

-

City

faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.Department of Animal Production,

Orcid

-

First Name

Abdelhalim

Last Name

El-Darawany

MiddleName

-

Affiliation

Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Email

el-darawany@zu.edu.eg

City

Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Orcid

-

First Name

Asmaa

Last Name

Sheiha

MiddleName

-

Affiliation

Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Email

asmaasheiha76@gmail.com

City

Zagazig University, Zagazig 44511, Egypt.

Orcid

-

Volume

32

Article Issue

1

Related Issue

29917

Issue Date

2022-01-01

Receive Date

2022-06-22

Publish Date

2022-01-01

Page Start

77

Page End

103

Print ISSN

1110-2594

Online ISSN

2682-3330

Article File

EJRS_Volume 32_Issue 1_Pages 77-103.pdf

PDF . 799.7kB

Link

https://ejrs.journals.ekb.eg/article_245484.html

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https://ejrs.journals.ekb.eg/service?article_code=245484

Order

245,484

Type

Original Article

Type Code

868

Publication Type

Journal

Publication Title

Egyptian Journal of Rabbit Science

Publication Link

https://ejrs.journals.ekb.eg/

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Article

Created At

22 Jan 2023