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188965

THERAPEUTIC POTENTIAL OF Citrus aurantium ON UROLITHIASIS INDUCED BY ETHYLENE GLYCOL IN MALE RABBITS

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Last updated: 04 Jan 2025

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Abstract

Nephrolithiasis is a complex physicochemical event which starts with urinary supersaturation and then leads to aggregation of renal crystal forming constituents within the kidneys.Researches gives much attention for better medical therapy and assess a satisfactory drug to prevent renal stone formation. The purpose of the study was to detect the effectiveness of Citrus aurantium (bitter orange) juice on ethylene glycol induced nephrolithiasis in male rabbits. Animals were divided into five groups (n=8) in which group 1 as control (C), group 2 as ethylene glycol non treated group (EG), group 3 as ethylene glycol group treated with bitter orange juice (EG+B.O), group 4 as ethylene glycol group treated with Citraforte (EG+C) and group 5 as ethylene glycol group treated with bitter orange juiceand Citraforte (EG+B.O+C).Ethylene glycol was givento group 2-5 in drinking water for 21st days for the induction of kidney stones then the treatments were continued for successive 3 weeks. The obtained results showed a significant increase(p≤0.05) in the serum level of total protein, albumin, phosphorus, uric acid, creatinine, blood urea nitrogen BUN,Malondialdehyde (MDA) and a significant decrease in calcium, catalase (CAT), Superoxidase dismutase(SOD) and glutathione (GSH) in the group of rabbits treated with ethylene glycol.All the estimated parameters showed an improvement in their values in the treated groups especially in group 5 which treated with bitter orange juice plus Citra forte. There was a detectable pathological lesion in the kidney tissues of rabbits in ethylene glycol group which improved with treatment by bitter orange juice and or Citraforte. In conclusion:Co-administration of bitter orange (Citrus aurantium) juice with Citraforte initiated a synergistic action for curing urolithiasis induced by ethylene glycol in male rabbits.  

DOI

10.21608/ejrs.2020.188965

Keywords

Citrus aurantium, urolithiasis, Ethylene glycol,Calcium oxlalates

Authors

First Name

Aya

Last Name

Metwally

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Aswan University, Egypt.

Email

-

City

Faculty of Veterinary Medicine, Aswan University

Orcid

-

First Name

Nabil

Last Name

Soliman

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Zagazig University, Egypt

Email

-

City

Faculty of Science, Zagazig University

Orcid

-

First Name

Amro

Last Name

Shalaby

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Zagazig University, Egypt.

Email

-

City

Faculty of Science, Zagazig University

Orcid

-

First Name

Anas

Last Name

Hassan

MiddleName

-

Affiliation

Department of Biology, Faculty of life Science, Tikrit University, Iraq.

Email

-

City

Faculty of life Science, Tikrit University, Iraq.

Orcid

-

Volume

30

Article Issue

2

Related Issue

22408

Issue Date

2020-07-01

Receive Date

2020-06-10

Publish Date

2020-07-01

Page Start

161

Page End

175

Print ISSN

1110-2594

Online ISSN

2682-3330

Article File

EJRS_Volume 30_Issue 2_Pages 161-175.pdf

PDF . 832.0kB

Link

https://ejrs.journals.ekb.eg/article_188965.html

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https://ejrs.journals.ekb.eg/service?article_code=188965

Order

5

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Original Article

Type Code

868

Publication Type

Journal

Publication Title

Egyptian Journal of Rabbit Science

Publication Link

https://ejrs.journals.ekb.eg/

MainTitle

THERAPEUTIC POTENTIAL OF Citrus aurantium ON UROLITHIASIS INDUCED BY ETHYLENE GLYCOL IN MALE RABBITS

Details

Type

Article

Created At

22 Jan 2023