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47473

CHROMOSOMAL ABERRATION AND PATHOLOGICAL ALTERATION AFTER COPPER OXYCHLORIDE FUNGICIDE INTOXICATION IN RABBITS

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Last updated: 04 Jan 2025

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Abstract

This study was conducted to examine the effect of Copper oxychloride fungicide is one of the most fungicide used in agriculture fields and crop storage on chromosomal aberration and some pathological alterations on rabbits. Forty five female rabbits divided into three groups (fifteen does each). The 1st group was fed ration without fungicide (control). The 2nd group was fed contaminated ration by Copper oxychloride (0.1184 g /Kg. BW/day as 1/20 LD50) and 3rd group was fed contaminated ration by copper oxychloride 0.2368 g /Kg. BW/day as 1/10 LD50 for sixty days. Three does and nine offspring were slaughtered from each group to obtained bone marrow for cytogenetic testing and histopathological examination.
These results significant increase (P< 0.05) in total chromosomal aberrations (gap formation, chromosome break, deletion chromosome, centromeric attenuations, centric fusion, end to end associations and ring chromosome) among different groups and among does in the same group and their progeny as fungicide treatment. On the other hand we showed significant increase (P< 0.05) in the incidence of clinical signs and congestion of the portal blood vessels with severe inflammation and cellular infiltration of hepatic parenchyma mainly lymphocytes in liver, and high increase congestion of the lining epithelium of renal tubules in the form of cloudy swelling and vacuolar degeneration in kidney in 3rd group more than the other group. The degeneration and atrasia of some ovarian follicles in ovary and increase congestion of the uterine blood vessels, focal areas of endometrial hemorrhages and hyperplasia of the endometrial lining epithelium of uterine horn associated with the increased of copper oxychloride /Kg. BW/day.
 Conclusively, these results indicated that fed contaminated ration with copper oxyhloride fungicide decreased the reproduction performance of female rabbits and make many deleterious effect on animal health.
 
  
 

DOI

10.21608/ejrs.2014.47473

Keywords

Rabbits, copper, fungicide, chromosomal aberration & pathological

Authors

First Name

Mohamed

Last Name

Saad

MiddleName

Fahmy

Affiliation

Department of Animal Biotechnology, Animal Production Research Institute, Dokki, Giza, Egypt.

Email

mohamedsfahmy@yahoo.com

City

ARC, Egypt

Orcid

-

First Name

Ayman

Last Name

Saeed

MiddleName

-

Affiliation

Department of Animal Biotechnology, Animal Production Research Institute, Dokki, Giza, Egypt PO Box 12816.

Email

aymansm66@gmail.com

City

Giza

Orcid

-

First Name

Ayman Hassan

Last Name

Ahmed

MiddleName

-

Affiliation

Poultry Production Department, Fac. of Agri., Ain Shams Univ., Egypt.

Email

-

City

-

Orcid

-

Volume

24

Article Issue

1

Related Issue

6597

Issue Date

2014-01-01

Receive Date

2013-10-02

Publish Date

2014-01-01

Page Start

89

Page End

102

Print ISSN

1110-2594

Online ISSN

2682-3330

Article File

EJRS_Volume 24_Issue 1_Pages 89-102.pdf

PDF . 550.5kB

Link

https://ejrs.journals.ekb.eg/article_47473.html

Detail API

https://ejrs.journals.ekb.eg/service?article_code=47473

Order

6

Type

Original Article

Type Code

868

Publication Type

Journal

Publication Title

Egyptian Journal of Rabbit Science

Publication Link

https://ejrs.journals.ekb.eg/

MainTitle

CHROMOSOMAL ABERRATION AND PATHOLOGICAL ALTERATION AFTER COPPER OXYCHLORIDE FUNGICIDE INTOXICATION IN RABBITS

Details

Type

Article

Created At

22 Jan 2023