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46698

DIETARY EXPOSURE EFFECT OF SUBLETHAL DOSES OF METHOMYL ON GROWTH PERFORMANCE AND BIOCHEMICAL CHANGES IN RABBITS AND THE PROTECTIVE ROLE OF VITAMIN E PLUS SELENIUM

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Last updated: 04 Jan 2025

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Abstract

The current study aimed to investigate the adverse effects of methomyl (Met) dose at different time intervals alone or with weekly Vitamin E+Selenium (ESe) injection on growth performance, blood biochemical parameters, and liver & kidney histopathological changes of New Zealand White (NZW) growing male rabbits. Five groups of 10 weaned rabbits (at 7 weeks of age and average initial live body weight of 824.40±71.0 g)were randomly assignedand used. The first group was served as control, the 2nd and 3rdgroups were received a daily dose of 10 and 20 mg kg−1 body weight (BW) of Met, while, the 4th and 5thgroups were received a daily dose of 10 and 20.0 mg kg−1 BW of Met with weekly subcutaneously ESe injection.
Results of the present study showed that: growth performance did not change significantly throughout experimental periods. Continuous exposure to Met alone or with ESe injection at 28 days showed a significant (P≤0.05 and 0.01) decrease in RBCs count. WBCs was increased significantly (P≤0.01) with exposure to Met only at 35 days. A significant decrease in total protein, urea, aspartate aminotransferase (AST) and alkaline phosphatase (ALP) due to exposure to Met was obtained. However, Alanine aminotrans ferase(ALT) and creatinine were increased significantly at 14 and 35 days. Degenerative changes and edematous fluid in the portal area with necrotic changes in hepatic cells were observed due to Met  effect. However, a few of proliferation of bile duct with edematous fluid in the portal area were affected of Met dose with ESe injection. Kidney damage due to Met exposure was involve ingrenal tissue damage with leukocyte infiltration, and degenerative changes due to Met exposure and ESe injection. Dietary Met administration with or without injection of ESe did not significantly affect most of carcass traits studied, except for heart, spleen, lung and fore limb percentages, which were significantly (P≤0.05) differed.
 In conclusion, the overall findings showed that Met exposure can cause biochemical changes, hepatic and renal damage to rabbits with low protection role of ESein NZW growing male rabbits.
 

DOI

10.21608/ejrs.2015.46698

Keywords

Rabbits, Methomyl, Growth performance, blood parameters, histopathology, carcass traits, vitamin E plus selenium

Authors

First Name

El-Sayed

Last Name

El-Sheikh

MiddleName

-

Affiliation

Plant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Email

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City

Zagazig

Orcid

-

First Name

Khaled

Last Name

Mahrose

MiddleName

-

Affiliation

Poultry Dept., Fac. Agric., Zagazig University, Zagazig 44511, Egypt

Email

ostrichkhalid@zu.edu.eg

City

Zagazig

Orcid

-

First Name

Ismail

Last Name

Ismail

MiddleName

-

Affiliation

Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig

Email

-

City

-

Orcid

-

Volume

25

Article Issue

1

Related Issue

6595

Issue Date

2015-01-01

Receive Date

2014-09-01

Publish Date

2015-01-01

Page Start

59

Page End

81

Print ISSN

1110-2594

Online ISSN

2682-3330

Article File

EJRS_Volume 25_Issue 1_Pages 59-81.pdf

PDF . 196.7kB

Link

https://ejrs.journals.ekb.eg/article_46698.html

Detail API

https://ejrs.journals.ekb.eg/service?article_code=46698

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4

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Original Article

Type Code

868

Publication Type

Journal

Publication Title

Egyptian Journal of Rabbit Science

Publication Link

https://ejrs.journals.ekb.eg/

MainTitle

DIETARY EXPOSURE EFFECT OF SUBLETHAL DOSES OF METHOMYL ON GROWTH PERFORMANCE AND BIOCHEMICAL CHANGES IN RABBITS AND THE PROTECTIVE ROLE OF VITAMIN E PLUS SELENIUM

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Article

Created At

22 Jan 2023