Thirty-six V-line male rabbits ten months age, average weight 3.5 kg were used. They were allocated randomly into six equal groups. First and second were served as a negative (NC) and positive (PC) control. Third group was injected by double dose (1mg/kg body weight) of ivermectin (IV) via subcutaneous injection, fourth, fifth and sixth groupswere treated with 5% garlic oil (GO), 5% cinnamon oil (CO) and 5% garlic oil + 5% cinnamon oil mixture (MO), respectively. Rabbits were treated GO, CO and MO received daily topically treatment for 7 successive days. Groups PC and IV were treated with paraffin oil and ivermectin. Blood samples were collected at 1, 7 and 14 days of treatment to biochemical analysis. Semen characteristics and reaction time (libido) were recorded.
Results showed thatthere were a significant (P≤0.05) decreased in total protein, albumin, globulin, testosterone, semen characteristics, TACin rabbits infested groups compared with NC group. But there were a significant (P≤0.05) increase in ALT, AST, creatinine, urea and uric acid, cortisol, T3 and T4, MAD in the rabbits infested groups compared with NC group. Rabbits treated with ivermectin recorded a significant (P≤0.05) decrease at 1 and 7 days in serum total protein, albumin compared with other groups, while, globulin decreased gradually from day 1, 7 and 14 comparable with other groups. Serum total protein, albumin, ALT, AST, creatinine, urea and uric acid were increased toward to NC group at 7thand 14th days of therapeutic.
Garlic and cinnamon oils caused a decrease in ALT, AST, creatinine, urea and uric acid with time compared with PC and IV groups.While, injected ivermectin for infested rabbits led to significant (P≤0.05) increase in cortisol, T3 and T4 hormones at 1th, 7th and 14th days. Likewise, testosterone significant (P≤0.05) increased at 7th and 14th day's similarity therapeutic by oil treated groups. Also, they recorded a significant (P≤0.05) decreasing at 14 days in MAD and significant (P≤0.05) increasing in TAC compared with other groups. Semen volume, sperm concentration, advanced motility and live sperm% were significantly decreased (P≤0.05) of infested rabbits compared with NC group, while abnormal sperm% increased. In the same context, the semen characteristics were significant increased in all therapeutic groups at 7th and 14th toward the NC group.
Conclusively, five percent of garlic or cinnamon oil is so effective in treating rabbits injured by Sarcoptec scabei compared to ivermectin with no side effects on liver and kidney functions or semen characteristics.