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221546

USE OF MESENCHYMAL STEM CELLS IN REPAIRING MALE INFERTILITY SUFFERING FROM OLIGOSPERMIA.

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Last updated: 04 Jan 2025

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Abstract

Germ cells must develop along distinct male paths to produce spermatozoa required for sexual reproduction. We show the expression of early germ cell markers cd105 in these cells. Mesenchymal stem cells (MSCs) are multipotent stem cells with abundant sources, active proliferation, and multidirectional differentiation potential. MSCs play a role through cell homing, secretion of active factors, and participation in immune regulation. Our findings provide direct evidence that human bone marrow cells and umbilical cord can differentiate to putative male germ cells and can provide a potential source of male germ cells that could sustain sperm production. This article summarizes the current research progress on mesenchymal stem cells in diseases related to infertility; advancements indicate that this emerging evidence contributes to solving problems related to male infertility. Furthermore, these data indicate the potential to harness the properties of stem cells for clinical applications and are also solve the problem of oligospermia persons and giving them absolve to become a normal person. According to count, before the injection the total number of cases were less than 15 million (100%), the mean was 6.04 ± 5.33 and after the injection of mesenchymal stem cells 8 cases (32%) were still less than 15 million but 17 cases (68%) were become more than 15 million, the mean was 23.02 ± 13.64, so p-value was <0.001 which is significant. Furthermore, According to vitality, before injection the minimum and maximum percent were (2%,28%, respectively), and also the mean was 13.0 ± 7.27. After the injection the minimum and maximum percent of vitality was (7,83%), the mean was 50.15 ± 25.47.  Moreover, the p-value is less than 0.001,  which is significant. Conclusively,the results from recent preclinical studies regarding stem cell-based therapies are promising. Stem cell-based therapies cast a new hope for infertility treatment as a replacement or regeneration strategy.    

DOI

10.21608/jpd.2022.221546

Keywords

Infertility, Mesenchymal Stem Cells, oligospermia, Stem cell

Authors

First Name

Lamiaa

Last Name

El-Naggar

MiddleName

-

Affiliation

Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

Email

attractive_ever@yahoo.com

City

1 Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

Orcid

-

First Name

Timor

Last Name

Khalifa

MiddleName

-

Affiliation

Faculty of Medicine, Azhar University, Egypt

Email

-

City

2 Faculty of Medicine, Azhar University, Egypt

Orcid

-

First Name

Bahgat

Last Name

Elfeky

MiddleName

-

Affiliation

Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

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-

City

Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

Orcid

-

Volume

27

Article Issue

1

Related Issue

28818

Issue Date

2022-01-01

Receive Date

2021-11-10

Publish Date

2022-01-01

Page Start

141

Page End

155

Print ISSN

1110-2543

Online ISSN

2682-3322

Article File

JPD_Volume 27_Issue 1_Pages 141-155.pdf

PDF . 512.5kB

Link

https://jpd.journals.ekb.eg/article_221546.html

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https://jpd.journals.ekb.eg/service?article_code=221546

Order

9

Type

Original Article

Type Code

867

Publication Type

Journal

Publication Title

Journal of Productivity and Development

Publication Link

https://jpd.journals.ekb.eg/

MainTitle

USE OF MESENCHYMAL STEM CELLS IN REPAIRING MALE INFERTILITY SUFFERING FROM OLIGOSPERMIA.

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Article

Created At

22 Jan 2023