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205856

EVALUATION OF CD MARKERS IN LYMPHOMA STEM CELLS BY FLOW CYTOMETRY

Article

Last updated: 22 Jan 2023

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Abstract

Most cancer were diagnosed by using a few simple stains and looking at the appearance of cells under the microscope. But there were only a few types of lymphoma cancer that could easily be distinguished in this way, and it often appeared that tumors of the same cell type behaved very differently in different individuals. It was obvious that something else was going on at the molecular level to account for these differences. As medical diagnosis progressed to the study of molecules, new techniques such as flow cytometry were devised to identify specific molecules, located on the surface of white blood cells (CD markers). In this study was carried out to assess the relation between lymphoma stem cells and 3 from specific CD markers which are CD 19, CD23 and CD 24by using flowcytometry technique to help diagnose lymphoma cancer.  Conclusively, in this study, CD 24 marker showed high positivity  in Hodgkin lymphoma disease, and can be used as a diagnostic marker in this type of haematological disease and also help in its treatment. In addition, it can help in diagnosis of Non-Hodgkin lymphoma patients. This  CD19 & CD23  can help in the diagnosis of  Hodgkin lymphoma patients as these two markers showed also positivity in these cases.             

DOI

10.21608/jpd.2022.205856

Keywords

Lymphoma stem cells, CD Markers, Flowcytometry, CD 19, CD23, CD 24

Authors

First Name

Hamada

Last Name

Fawzy

MiddleName

-

Affiliation

Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

Email

dr.hamada1999@gmail.com

City

Genetic Engineering and Biotechnology

Orcid

-

First Name

Randa

Last Name

Talaat

MiddleName

-

Affiliation

Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

Email

-

City

Genetic Engineering and Biotechnology

Orcid

-

First Name

Hossam

Last Name

Fahmy

MiddleName

-

Affiliation

Faculty of Medicine, Ain Shams University, Egypt

Email

-

City

Faculty of Medicine, Ain Shams University, Egypt

Orcid

-

Volume

27

Article Issue

1

Related Issue

28818

Issue Date

2022-01-01

Receive Date

2021-10-14

Publish Date

2022-01-01

Page Start

31

Page End

40

Print ISSN

1110-2543

Online ISSN

2682-3322

Article File

JPD_Volume 27_Issue 1_Pages 31-40.pdf

PDF . 564.3kB

Link

https://jpd.journals.ekb.eg/article_205856.html

Detail API

https://jpd.journals.ekb.eg/service?article_code=205856

Order

3

Type

Original Article

Type Code

867

Publication Type

Journal

Publication Title

Journal of Productivity and Development

Publication Link

https://jpd.journals.ekb.eg/

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Article

Created At

22 Jan 2023