A pot experiment was carried out during two successive seasons, 2007 and 2008 to study the tolerance of acokanthera plants to saline water irrigation. The data revealed that there were significant reductions in plant height, stem diameter, number of leaves with saline water treatments above 3000 ppm, the decreases were in proportion to the increase in salinity level. Also, the data indicated that in both seasons, there were no significant decreases in fresh weight of leaves and stems as the level of salinity increased to 3000 ppm. A marked increase , but not significant, in the fresh weight of roots, in both seasons, was obtained with the lowest level of salinity(1500 ppm).Irrigating the plants with saline water at 1500 or 3000 ppm insignificantly reduced leaf area, in both seasons. There were significant increase in dry weight of leaves when plants were irrigated with the lowest salinity levels (1500 and 3000 ppm) as compared with the control, irrigating the plants with stalinized water above 3000 ppm significantly decreased the dry weight of leaves, the dry weight of stems markedly increased with the level of salinity at 1500 ppm. All saline water treatments decreased the content of chlorophyll -a and-b. Growing plants under salinity stress markedly decreased the content of total carbohydrates. All the saline water treatments caused a remarkable increase in the proline content over the control plants. In both seasons, the N, P and K contents of different plant parts decreased as salinity level increased, whereas Na, Ca, and Cl contents increased. Generally, this plant can be irrigated with saline water at 3000 ppm without harmful effect.