ManageChatDiscover
42267

HEPATOPROTECTIVE AND ANTIDIABITIC EFFECTS OF AQUEOUS Moringa oleifera LEAVES EXTRACT ON EXPERIMENTAL RATS

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

This study was designed to determine the total phenols , flavonoids and antioxidative effect of aqueous Moringa  oleifera  Leaves  extract (AMLE) on the biochemical profile of hepatic dysfunction and diabetic male rats. It was found that AMLE contained 698.82 mg/g of total phenolic compounds , 26.33 mg/g of total flavonoids and antioxidant activity (DPPH) recorded 81.6%. Also, the results indicated that e-vanillic acid (1988.32 ppm) and syringic acid (898.25ppm)were the dominant phenolic compounds in AMLE. Concerning the biological assay, the obtained results showed that there were significant differences between only Lipopolysaccharides (LPS) treated group and those treated with LPS followed by AMLE or AMLE followed by LPS. Where, it could be noticed that there were significant decreases in all liver function values except for serum albumin,which increased and reached to 4.00 mg/dl in treated group with AMLE followed by LPS. In addition , AMLE improve kidney functions. Also, antioxidant enzyme concentrations (SOD) increased in  treated group with AMLE  group  followed by treated group with  LPS and reached 30.33 U/L. On the other, hand the treatment with AMLE decreased LDL-cholesterol and increased HDL-cholesterol levels at the end of experimental period compared with those of  LPS treated group . As biochemical indices, it could be noticed that blood glucose recorded an improvement in group treated with amaryl drug (167.66 mg/dL) and AMLE group (180.66 mg/dL) compared with Streptozotocin (STZ ) group (306.66 mg/dL). Conclusively, it briefly could concluded that aqueous Moringa olifieria leaves extract had vital effects to prevent LPS induced hepatic dysfunction and gluscose blood level by its high content of polyphenols.        

DOI

10.21608/jpd.2016.42267

Keywords

Moringa oleifera, LPS, STZ, Liver function and Diabetic

Authors

First Name

Gehan

Last Name

Ghoneim

MiddleName

-

Affiliation

Food Industries Department, Faculty of Agriculture, Mansoura University, 35516, Mansoura, Egypt.

Email

-

City

Mansoura

Orcid

-

First Name

Faten

Last Name

Ibrahim

MiddleName

-

Affiliation

Food Industries Department, Faculty of Agriculture, Mansoura University, 35516, Mansoura, Egypt.

Email

-

City

Mansoura

Orcid

-

First Name

Rania

Last Name

El-gammal

MiddleName

-

Affiliation

Food Industries Department, Faculty of Agriculture, Mansoura University, 35516, Mansoura, Egypt.

Email

-

City

-

Orcid

-

Volume

21

Article Issue

3

Related Issue

6560

Issue Date

2016-08-01

Receive Date

2016-05-06

Publish Date

2016-08-01

Page Start

203

Page End

219

Print ISSN

1110-2543

Online ISSN

2682-3322

Article File

JPD_Volume 21_Issue 3_Pages 203-219.pdf

PDF . 726.0kB

Link

https://jpd.journals.ekb.eg/article_42267.html

Detail API

https://jpd.journals.ekb.eg/service?article_code=42267

Order

1

Type

Original Article

Type Code

867

Publication Type

Journal

Publication Title

Journal of Productivity and Development

Publication Link

https://jpd.journals.ekb.eg/

MainTitle

HEPATOPROTECTIVE AND ANTIDIABITIC EFFECTS OF AQUEOUS Moringa oleifera LEAVES EXTRACT ON EXPERIMENTAL RATS

Details

Type

Article

Created At

22 Jan 2023