Background: Cerebral stroke is a pathological condition whereby normal blood flow to a specified part of the brain is obstructed, depriving it of nutrients and oxygen supply. Deprivation for 1 minute can lead to reversible symptoms, such as loss of consciousness. Basic nursing education on neurologic problems constitutes one of the biggest challenges for critical care nurses. Aim of the study: Explore the effect of an educational program on nurses' knowledge regarding the care of patients with cerebral stroke. Subjects and method: Design: A quasi-experimental design was utilized to conduct the study. Setting: The study was conducted in the intensive care unit at Port Said General Hospital. Subjects: convenient sample (50) nurse. Tools:  Nurses' knowledge questionnaire. The Results: (30%) of studied nurses had satisfactory total knowledge pre-program compared to (92%) immediately post educational program implementation and (90%) of them follow up after educational program implementation.  Conclusion: There was a statistically significant difference in nurses' knowledge between pre, immediately, and post-program implementation Recommendations: Providing ongoing educational program on nurses' knowledge regarding care of patients with cerebral stroke.