Background: Satisfaction of patients is a watchword for organizational success. The hospital infrastructure has been associated with health care quality and associated with the satisfaction of clients. So, the aim of this study is to assess infrastructure and its relation to patient satisfaction With the quality of nursing  care at Port Said setting hospitals. Subjects and Methods: Design:   A descriptive correlational. Setting: As-Salam hospital  and El-Zohor hospital at Port Said. Subjects: included 121 from As-Salam hospital (20 males and101 females) and 79 from El-Zohor hospital (15 males and 64 females) they selected randomly and Convenient Sample of patients in all inpatient units from study setting for two months (100 from Al- Salam hospital (40 male and 60 femal) and 100 (50 male and 50 female) from El- Zehour hospital). Tools: Quality Standard for Hospital Infrastructure, Quality of Nursing Care and Patient Satisfaction Questionnaire. Results: It shows that, a significant positive correlation between the quality of nursing care and patient satisfaction in As-Salam hospital and El-Zohor hospital. Finally, there was no statistically significant difference between the studied hospitals in the quality standards for hospital infrastructure except the inpatient quality standard. Conclusion: it was concluded that there was a significant positive correlation between total patient satisfaction and overall quality of nursing care in As-Salam hospital and El-Zohor hospital. Recommendations it is necessary to perform a continuous evaluation of the hospital infrastructure and also continuous measure patients' satisfaction with the nursing service provided.