Background: Applying standardized perioperative guidelines for cardiac surgery helps to improve patient satisfaction, and quality of care, improve staff education and decrease organizational costs also promotes the outcome of patients undergoing surgery during their entire perioperative trip. Aim of the study: Effect of education guidelines on health outcomes and satisfaction for patients undergoing cardiac surgery. Design: A quasi-experimental design was a charity for this study. Setting: This study was shown in the cardiothoracic surgery department and also in the outpatients' clinic at the cardiothoracic and vascular surgeries center at Mansoura University. Subjects: Purposive sample patients undergoing cardiac surgery including all adult patients who were admitted for 6 months nearly 120cardiac patients. Tools: Three tools were used for data gathering, demographic characteristics and perioperative knowledge tool for cardiac surgery patients, Rand Patients' Health Outcomes Scale tool, and Theresa Bucco- Satisfaction scale tool. The results: Before applying educational guidelines, there were no significant differences between studied patients in perioperative knowledge, health outcome, and satisfaction. However, after applying health education guidelines the perioperative knowledge, health outcome, and satisfaction improved. Conclusion: Applying health education guidelines have a significant positive impact on patients' knowledge, and health outcome as promotes quality of care, decrease organizational costs, also the satisfaction of patients undergoing surgery. Recommendation: Training the cardiac patients should be existing for preoperative assessment nurses who are training patients to be prepared for their surgical pathway.