Background: Dialectical Behavioral Therapy is a modality of cognitive behavioral therapy, which directs the process on the synthesis of opposites and the modification of maladaptive behaviors. It cognizes individuals with four significant compounds of skills to manage massive emotions, and innervate coping skills. Aim: This study aimed to evaluate the effect of dialectical behavioral therapy on depressed patients' suicidal attempts and non- suicidal self-injuries. Subjects &Method: Design: A control time- series quasi-experimental research design used. Setting:Eastern Governance for mental health hospital. Subjects: A total number of 40 patients participated in the study. Tools: Hamilton Depression Rating Scale, Non-Suicidal Self-Injury Assessment Tool and Lineman Suicide Attempt-Self-Injury Interview were used in data collection. Results: Significant reduction in suicidal attempts' mean scores throughout the program and follow up phases among the DBT group with high effect size procured between both DBT and usual care groups ( Cohen's d = ranged from  0.500000 to 1.31689). Conclusion: This research showed that Dialectical Behavioral Therapy is a salutary, profitable and pre-eminent approach can be used with suicidal and NSSI patients as compared to usual care. Recommendations: There is imperious need to expand the use of this therapy with psychiatric patients (e.g. anxiety disorders; PTSD patients).