Background: Applying of ventilator bundle of care according to evidence-based practice guidelines are expected to improve weaning, provide quality of care, improve patient outcomes, and reduce the risk of complications with ventilated patients. Aim: The researchers wanted to assess how effective a bundle of care was at weaning mechanically ventilated patients in the intensive care unit and cardiac care unit. Subjects and Method: The study used a quasi-experimental research design. A purposive sample of mechanically ventilated patients (60) at both insurance hospitals (Al-Salam) in Port Said governorate and health ministry hospital (Sherbin central) in Dakahlia governorate's critical care unit and cardiac care unit. Tools: Tool I: It includes two parts, part 1: Sociodemographic characteristics, part 2: patient's assessment questions (patient's medical history), Tool (II): Is Ventilator bundle compliance checklist Tool (III): Is Burns' Wean Assessment Program (BWAP) scores. Results: This study revealed a statistically significant correlation between the studied patients’ total Burns' weaning assessment and compliance with ventilator bundle of the studied patients with p-value