Background The burden associated with caring for Alzheimer's patients not only affects the health of family caregivers and increases their mortality risk, but also reduces the quality of caregiving .Aim: To assess burden and quality of life of caregivers of Alzheimer's patients .Design: A cross-sectional descriptive research design was applied. Setting: This study was carried out at neurologic outpatient clinics of psychiatric hospital in Port Said city. Subjects: A Purposive sample of all family caregivers of Alzheimer's patients (110) were included. Tools of data collection: Family Caregivers' Socio-Demographic Information Questionnaire; Caregivers' Burden Scale; and Short Form Health-Related Quality of Scale were used. Results: Mean age of caregivers was 41.36 ± 12.74 and more than two-thirds of them were females. Also, physical burden was the most prevalent at 19.45±3.47 among caregivers. Furthermore, the highest percentage 71.8% of caregivers reported having poor quality of life concerning limitations of activities. Additionally, there was a highly statistically significant positive correlation between the total quality of care of caregivers of Alzheimer's patients with caregiver's total burden assessment at P<0.05. Conclusion: Total burden assessment among the caregivers of Alzheimer's patients was 51.43±9.20; with a higher percentage of the caregivers of Alzheimer patients had the total average quality of life, while a lower percentage of the caregivers of Alzheimer patients had a total average good quality of life. Recommendations: Continuous health educations programs for caregivers of Alzheimer's patients are necessary needed and further studies using a large study sample size in different settings are highly recommended.