Background: Schizophrenic patients have abnormalities in basic dimensions of personality. Self-esteem might be a driver or resource for the development of personality traits. Aim: This study aimed to evaluate the association between self-esteem and personality traits among schizophrenic patients. Subjects and Method:  Design: A descriptive correlational research design was utilized. Setting: This study was carried out at inpatient units in Port Said Psychiatric Health Hospital.Subjects: The study subjects consisted of 104 schizophrenic patients from the above-mentioned setting. Tools:  Three tools were used to collect data which were the Rosenberg Self-Esteem Scale, and Big Five Inventory, in addition to personal and Clinical questionnaires. Results: Most of the studied patients had a high score of self-esteem. About half of the studied patients had alow score of extraversion personality. Conclusion: The study concluded that there are highly positive statistically significant relationships between self-esteem and extraversion, agreeableness, conscientiousness, and openness personalities and there is no statistically significant correlation between self-esteem level and neuroticism personality. Recommendation: The study recommended an educational session for schizophrenic patients about specific self-esteem enhancement interventions. An educational session is recommended to psychiatric nurses about preferred approaches to enhance patients' self-esteem and improve their personality from being disordered.