Background:TotalKnee Replacement (TKR) remains the surgical gold standard treatment for patients suffering from end-stage osteoarthritis (OA) to restore the quality of life in patients with Knee osteoarthritis. Aim: This study aimed to assess quality of life for patients after total knee replacement surgery. Subjects and Method: design: A descriptive research design was utilized. Setting: study carried out at outpatient clinics in University Mansoura Hospital. Subjects: Purposive sample of total knee replacement patients (100).  Tools: Tool I:  A Structured interviewing, It includes two parts, part 1: Patient's demographic characteristics, part 2: patient history and joint level factors, Tool II:  Short form survey 36 questions (SF-36) to assess quality of life.  Results: This study showed that 62% of the studied patients had good quality of life. Also, the only factors associated with quality of life in patients post total knee replacement surgery was joint level factors. As well as clarified that 37% of studied patients had satisfactory in quality of life from one to six months after surgery, while 63% of them had unsatisfactory. Also, 83% of them had satisfactory in quality of life from 7 to12 months after surgery, while 17% of them had unsatisfactory in quality of life. Conclusion:  About two thirds of the studied patients had good quality of life. The highest percentage of good quality of life was Physical functioning domain followed by Mental Health domain. Also, there was only significant relation between joint level factors and levels of quality of life among patients with total knee replacement. Moreover, The majority of them had satisfactory in quality of life from 7 to12 months after surgery Meanwhile there was only significant relation between floor number and levels of quality of life. Recommendations: the study recommended Performing Physiotherapy Exercises and Activities of Daily Self-Care.