Background: An information technology system has developed rapidly in recent years and become an indispensable part of health care services as in the very field. Aim:  This study was to examine factors contributing to the application of information technology system and their benefits. Subjects and method: Design: A descriptive correlational research design was used Subjects: Sample of staff nurses(180) were included.  Setting: Oncology Center in El Mansoura University. Tools: Data were collected by four tools  (1)  personal and job characteristics, (2) organization factors that include (a) user involvement scale, (b) a management support scale, (3) information systems use a scale, and 4) benefits use the information systems scale. Results revealed that (55%,51.7% and 58.3%) of the study nurses had a moderate level toward user involvement, management support, and information systems use benefits respectively . Also, 53.4%  of the study nurses had a high level related to information systems use. Conclusion: There was a highly significant positive correlation between total benefits use information systems of the studied nurses and their user involvement, management support and information systems use. Therefore, this study.  Recommendations: Provide many chances for the continues training and awareness of healthcare professionals for promoting use electronic medical records efficiently and study nurses' attitudes and satisfaction with electronic medical records, medication administration records systems, and nearby paperless hospitals and measuring the quality of the Ibn Sina system for managing medical documents by applying the Six Sigma methodology.