Background: Characteristics of work climate and job empowerment has a great impact on staff performance. Therefore, creating and examining a positive work climate that directly influences staff nurses' moral, behavior and attitude is main concern for health care providers Aim: The study aimed to investigate the relation between characteristics of work climate and job empowerment at Mansoura University Hospital. Sbjects and method:  design: A descriptive correlational study was utilized. Setting: this study conducted  in Mansoura University Hospital.  Subjects:  A sample of all staff nurses with total No (110) who were working in Mansoura University Hospital. Tool: Nurses' perception of work climate characteristics questionnaire and empowerment questionnaire. Results: Revealed that more than half of nurses had high work climate perception. Most work climate perception of staff nurses pertained to customer service, followed by quality, work facilitation and Communication. Also, the most staff nurses were empowered, and the highest mean score was for opportunities, meanwhile the lowest mean score for resources.. Conclusion: there was a highly statistically significant correlation between characteristics of work climate and job empowerment. Recommendations: Nursing leaders and hospital managers should provide a work climate that allows nurses to share ideas, team spirit and creativity. Furthermore, highlight the importance of empowerment strategies that allow nurses to work in a healthy working environment.