Background: Leprosy is caused by mycobacterium leprae and spread among those living in poverty. stigma has been associated with leprosy. Aim: Assess quality of life among leprosy patient. Subjects and method: .Design: A descriptive  cross-section design was adopted on the current study .Setting: This study was carried out Hospital of Dermatology, Venereal and leprosy in Dakahelia Governorate. Subjects: A purposive sample was used to this study and compromised  of 325. Tool: Two tools were utilized to collect necessary data in this study. Tool I, Structured interview. Tool II, the World Health Organization Quality of Life (WHOQOL) –BREF. Results: The present of study showed that, more than half of leprosy patients (55.4%) rated their quality of life as very poor. most of leprosy patients had a poor knowledge (99.7%) and had negative attitudes toward leprosy. And also there are appositive statically significant relation between four domain of quality of life, age ,and family number. Conclusions: Majority of leprosy patients were not working, low education stander and living in rural area, most of leprosy patients had a poor knowledge and had negative attitudes toward leprosy. Recommendations:  contagious training program about leprosy for leprosy patients  through visual aids such as posters and clear language booklets to improve their knowledge.