Background: Burns can lead to severe mental and emotional distress. Aim:  Assess effect of breathing exercise on reducing pain associated with dressing among hospitalized burned patients. Subjects and method: Design: A Quasi-experimental research design was utilized; the study was carried out. Setting:  study performed in center of burn and beauty center at Mansoura University Hospital. Subjects: carried out on 73 burnt patients attended to study setting.  Tools: Two tools were used to collect data of the current study. Tool (I) Patient's questionnaire which consist of three parts; Part 1: Socio demographic data Part 2: Patient burn history: Part 3: The Burns Specific Pain Anxiety Scale and Tool (II): Observational Checklist which consist of three parts; Part 1: "Burn Parameters" Part 2: University of Alabama at Birmingham UAB3 Relaxed Behaviors Checklist. Results:  There were an improvement in results of burn specific pain anxiety scales score, UAB Pain Behavior Scale and relaxed behavior after application of breathing exercise. The study Conclusion: that using of breathing exercise are very important to reduce pain and anxiety associated with burn dressing change for hospitalized burned patients. Recommendations:  Training programs should be applied for patients on breathing exercise as daily routine nursing care to reduce pain and anxiety associated with dressing change.