Background: chronic hepatitis C virus is a major cause of liver-related morbidity and mortality and is known to impair activities of daily living. Direct-acting antivirals have demonstrated high efficacy to achieve sustained virological response in chronic hepatitis C patients. Aim: This study aimed to assess effect of direct acting antiviral treatment on daily living activities for patients with hepatitis C virus. Setting: This study conducted at El-Mataria Daqahlia Health insurance hospital in El-Mataria city, Daqahlia and EL-Tadamon Hospital in Port –Said city. A descriptive sample of 100 male and female adult patients were included in the study.  Tools of data collection: Three tools were used to collect study data. First tool is a questionnaire used to assess patient's demographic data, medical and surgical history, the second tool is care dependency scale used to assess level of patient dependency and third tool was daily living scale to assess daily living activities of the study patients. Results: the study results revealed that the majority of sample 73%were dependent as an effect of treatment mostly in activities which need more effort or more cognitive abilities as housekeeping and learning ability while 27% were independent independent mainly in personal activities as continence, getting dressed and undressed. Conclusion. The majority of the sample were nearly independent in personal ADL and physical activities, while about one fourth one- fourth were dependent in other activities which need more effort or more cognitive. Recommendations: Assessment of patient physical, psychological, social and spiritual health behaviors should be a part of routine patient's health assessment. Further study is recommended in a larger sample with considering factors could affecting patient's response to viral hepatitis treatment.