Background:Endometriosis is a disease affect Women' health and Quality of life especially in child bearing age. Aim: Assess the Health- Related Quality of life among Endometriosis Women in Maternal and Child Health Centers in Damietta. Design: A descriptive study was used. Setting: Gynecology and Obstetrics out patient at three Maternal and Child Health centers; New Damietta MCH center, Shata MCH center and KaferShehata MCH center in Damietta city. Subjects: A total of 100 women with surgically diagnosed endometriosis were purposively selected. Tools:  Include; structured interviewing questionnaire and the Endometriosis Health Profile (EHP-30+5). Results: shows that 83.0% of women had infertility. There was a delay in seeking treatment that ranged between 2-10 years. Endometriosis had a negative impact on woman's quality of life and there is statistically significant relation between stages of endometriosis and the negative  aspect  of  women's quality of life in terms of physical, psychological, sexual, educational and working life. Recommendations: there is a need for teaching patients to avoid the delay in seeking treatment. As well as how to cope with chronic pelvic pain  and to teach patients how to strengthen relationships   with their partner and friends, so they will be supportive in coping with the disease instead of drifting apart due to potentialmisunderstandings.Conclusion: There was a delay in seeking treatment for endometriosis despite its negative impact on woman's quality of life in terms of  physical, psychological, sexual, educational and working   life.