Background: Health risk behaviors are one of the most important aspects of human health. The aim of this study was to determine the health risk behaviors among Port Said University students and identify factors related to it. Setting: the study was carried out at all faculties of Port Said University. Sample: the sample size was 700 students stratified randomly selected. Research design: a cross sectional descriptive design was used. Data collection tools: Self administered a standardized questionnaire was used to collect data, it includes two parts part one includes socio demographic data, the second part includes: modified and tested version of National College Health Risk Behavior Surveillance System Questionnaire (NCHRBSS).Results: The results indicated that the majority of the studied students, 79.5% never or rarely wore a seat belt while driving, 6.3% of students had participated in physical fights, 10.9% of the students were planning suicide attempts, 3.0% were drug users,2.9% were alcohol consumers, 11.0% were smoked, and 6.3% of the student were sexually active. In addition, 45.5% of the students had unhealthy dietary habits, where 69.0% of them did not practice physical activities regularly. Conclusion: physical inactivity had been the most prevalent health risk behavior followed by, unhealthy dietary habits, then unintentional injuries. Recommendations: physical activity and nutritional programs should be carried to university student's healthy lifestyle behaviors.