Background: Nurses are a main group of health service providers, but they have to face physical and psychological problems such as permanent confrontation with the patient, being exposed to health hazards. Nurses need to be motivated to accomplish their tasks, provide quality care. Motivation at work was found to be closely linked with job satisfaction and psychological well-being. Aim: the aim of the study was to investigate the relationship between psychological wellbeing and work motivation among staff nurses in Governmental Hospitals in Port Said. Subject and Methods: The current study utilized a descriptive correlational design. The study population included all staff nurses with total number 274 at inpatient units working in four hospitals namely (Port Said general hospital, Elnasr hospital, Elzohor Central hospital and Port Fouad general hospital), used two tools: Ryff Psychological Wellbeing Scale (Ryff Scale), Work Preference Inventory scale, a personal and job characteristics questionnaire sheet was added. Results: The high percentage of nurses participate in this study were females 94.2%, less than three quarter of studied staff nurses had high level of the total psychological well-being (71.5%), the majority of the studied staff nurses had highly total scores of work motivation (77.4%).Conclusions: there is a significant correlation between psychological wellbeing and work motivation among staff nurses in governmental hospitals at Port Said. Recommendations: Nurses should improve their psychological wellbeing state. In addition, nurses' managers should motivate nurses through increase incentives, appreciate and acknowledge all nurses working in hospitals.