Self-directed learning has proven to be advantageous for the students to conduct lifelong, satisfactory and independent learning while, problem-based learning is a constructive learning approach by enabling students to find solutions for the complex real-world problems. Aim of the study: The current study aimed to determine the relation between self-directed learning readiness and problem-based learning approach as perceived by nursing students. Design: A descriptive correlational research design was utilized. Sample: All target of nursing students (371) included in the studying in the second semester at all levels in the academic year 2017-2018 was recruited from the faculty of nursing in port-said university. Tools of data collection: Self-administered questionnaires \ scales were used to assess self-directed learning readiness and the problem-based learning approach as perceived by nursing students. Results: Students had moderate level of self-rating skills of self-directed learning, self-directed learning readiness, and low level of self-regulation responses (57.1%, 60.6%, 56.4% respectively) While, (50.4%) of students obtained low perception of problem-based learning approach. Conclusion: There was a positive statistically significant correlation (P≤0.001) between self-directed learning readiness and problem-based learning approach. Recommendations: Educational institutions in various fields must adopt the problem-based learning approach as a learning strategy and develop strategies to overcome obstacles that hinder application.