In order to develop a high quality, performance-oriented nursing staff, every nursing leader strives to inspire followers to create engaged and enthralling teams that work beyond the needs of the job. Aim:This study aimed to investigate team work effectiveness and its relation with transformational leadership as perceived by nurses at Port Said general hospitals. A descriptive correlational research design was utilized with a sample of nurses who were working in Port Said city general hospitals namely: Port-Said general hospital and El-Zohour general hospital. A sample size was 178 nurses. Two tools were used to collect the data namely: Team effectiveness questionnaire and transformational leadership scale. Results of the study showed the majority of nurses (92,7%) adopted that transformational leadership leads to team effectiveness. Conclusion: The findings of the present study revealed that highest percentage of studied nurses were working in effective team work and under leaders adopting transformational leadership style with statistically significant relation. Recommendations: Designing and applying training strategy and continuing education programs about the importance of team work effectiveness in hospital environment and how to apply transformational leadership style.