Background:Entrepreneurship and innovation are widely regarded as an important basis for competitive advantage in work environment and enhancing capabilities for work growth and the wealth of nations. Aim: This study aimed to examine the relation between entrepreneurship and work innovation among nurse managers at Port Said governmental hospitals.Subjects and Method: A descriptive correlational research design was utilizedfor the present study.Setting: This study was carried out at Port Said seven governmental hospitals namely:  Port-Said general hospital, El-Zohour general hospital, El-Nasr hospital, Ophthalmology hospital, fever hospital, Chest Disease hospitaland Obstetrics and Gynecology Specialist hospital, all hospital affiliated to Ministry of Health.Subject: This study was included (101) nurse managers. Tools of data collection: Two tools were utilized namely: The characteristics of entrepreneurship questionnaire and work innovation questionnaire.Results: The study revealed that the majority of nurses' managers haven't entrepreneurial characteristicsand the majority of nurses' managers haven't work innovation. Conclusion:There was statistically significant positive correlation between nurse managers' characteristics of entrepreneurship and the work innovation. Recommendations: Improve self-confidence by further engagement and encourage their ability to achieve. Attend conferences, workshops and training program about entrepreneurship characteristics and work innovation to create an entrepreneurial character and enhance innovative behavior.