Background: The interest in work and health organization in relation to quality of work life (QWL) has increased due to many positive outcomes as job satisfaction, increased productivity and less occupational stress. Aim: The study aimed to investigate the relationship between quality of work life and occupational stress among head nurses at Port Said Hospitals. Methods: A descriptive correlation research design was utilized with total sample of (85) head nurse. Tools of data collection: The data were collected by using two tools; Quality of nursing work life scale (QNWL) and Occupational stress scale. Results: Revealed that 51.8% of head nurses had high QWL and the highest percent of them had high quality of work life for the work context. Also, it was observed that 77.6% of head nurses had low stress level and 41.2% of them had high stress level for physician related stressors. Conclusion:The findings pointed to, that there was a negative a statistically significant correlation between quality of work life and occupational stress among head nurses. Recommendations: Therefore, the findings pointed for upgrading nurses' QWL through development of new strategies and systems to enhance work environment. And using advanced coping strategies to eliminate stress level among nurses.