Background: Worldwide, chronic obstructive pulmonary disease (COPD) is in the spotlight because of its morbidity, mortality and high prevalence. In Egypt is highlighted as a major public health problem. The aim of the present study was to evaluate the impact of an educational program on knowledge, practice, and self-efficacy of patients with stable chronic obstructive pulmonary disease. Quasi- experimental research design was utilized in this study. The sample was consisted of all available patients with stable COPD during the time of data collection. Four tools were used to collect data: first; Structured interview questionnaire which consisted ofsocio-demographic characteristics, and medical history. Second; the Bristol COPD Knowledge Questionnaire (BCKQ), third; Observational checklist which consisted of breathing exercises& inhaler use, and fourth; Self-Efficacy Scale for Patients with COPD. The result of the study concluded that  there was a highly statistically significant difference in patients' total knowledge and practice pre and post program & pre and follow up program. Concerning total Self Efficacy there was no statistically significant difference between pre and post & pre and follow up scores, but there was a highly statistically significant difference between pre and post program regarding all self-efficacy issues except with weather ∕environment, while there was no statistically significant difference between pre and follow up program in all self-efficacy issues except in negative affect issues. The study concluded that after implementation of the educational program, remarkable improvements were occurred in knowledge, practice, and self-efficacy sub scores. The study recommended Continuous monitoring and evaluation of self-efficacy for patients to enhance disease management through establishing a rehabilitation program for patient to improve their self-efficacy. Promotion and enhancement of the self-care modalities to the patient; a strict written instruction with pictures about disease process, allowed foods , rest and physical activities and follow up should be continued after termination of educational program.