Background: Worldwide, chronic obstructive pulmonary disease (COPD) is in the spotlight because of its morbidity, mortality and high prevalence. In Egypt is highlighted as a major public health problem. The aim of the present study was to evaluate the impact of an educational program on knowledge, practice, and self-efficacy of patients with stable chronic obstructive pulmonary disease. Research Design Quasi- experimental research design was utilized in this study. Subject& Methods, the sample was consisted of all available patients with stable COPD during the time of data collection. Two tools were used to collect data: Structured interview sheet which consisted ofsocio-demographic characteristics, and medical history. and; Self-Efficacy Scale for Patients with COPD. The result of the study concluded that there was no statistically significant difference between pre and post & pre and follow up scores, but there was a highly statistically significant difference between pre and post program all self-efficacy factors except with weather ∕environment, while there was no statistically significant difference between pre and follow up program in all self-efficacy factors except in negative affect factor. Conclusion, the study concluded that after implementation of the educational program, remarkable improvements were occurred in knowledge, practice, and self-efficacy sub scores. Recommendation, the study recommended continuous monitoring and evaluation of self-efficacy for patients, to enhance disease management through establishing a rehabilitation program for patient, and to improve their self-efficacy. Promotion and enhancement of the self-care modalities to the patient; a strict written instruction with pictures about disease process, allowed foods , rest and physical activities and follow up should be continued after termination of educational program.