Background: It is vital to increase nurses' quality of work life because this has the potential both to improve organizational citizenship and ensure an adequate nursing work force. Aim: To explore the relationship between organizational citizenship behavior and quality of work life among nurses in Port Said hospitals. Subjects and Method: A descriptive comparative correlation research design was utilized. Setting: This study was conducted in General Port Said hospital and Atta Specialized hospital. Subjects: A sample of 207 nurses who at job in time of the study. Tools of data collection: Two tools included organizational citizenship behavior scale and quality of work life components. Results: Showed that, high percentage of studied nurses agreed on organizational citizenship behavior scale. It was determined that the nurses obtained the highest score from the altruism, conscientiousness dimension followed by courtesy. Regarding quality of work life components, it was found that around half and more of the studied person agreed on overall quality of work life. Conclusion:There was positive correlation among organizational citizenship behavior and dimensions of quality of work life. Recommendation: Increase training programs in hospitals help nurses to achieve the required skills and improve communication among nurses.