Background: Alteration in sensory perception that occurs during anti neoplastic chemotherapy can seriously affect the health and nutritional status of patients, everyday life activities and recovery possibilities. Aim: This study aimed to assessment of sensory perception alteration for patients receiving anti neoplastic chemotherapy. Subjects and method: Across section study design using a mixed-methods study combining qualitative and quantitative approaches of data collection was adapted. A convenient sample from patients receiving anti neoplastic chemotherapy that were available within 6 months. The present study included a group of 100 Cancer patients receiving ACH. Data were collected through Sensory administrated questionnaire for quantitative data and interview schedule for qualitative data collection. Results: The majority of the patients in the study displayed alteration of taste perception reported the highest mean value (66.35) followed by sense of tactile perception alteration (57.54) then visual perception alteration(45.41) followed by hearing perception alteration (39.81) then sense of position perception alteration(37.97) and finally was sense of smell perception alteration (34.61) ,there are statistically significant relation between sense of vision and sense of tactile perception alteration with the starting date of ACH at p value ˂ 0.05. Also, six themes were identified in the current study which reported that more than half of patients express taste perception alterations. Recommendations: conducting educational programs to improve patient's knowledge and a wariness regarding receiving of ACH. Conclusion: Sensory perception alterations during ACH are significant complaints of cancer patients. In addition to reducing life satisfaction, poor compliance and even decreased response to therapy.