Background: Organizational commitment has been extensively researched as an important factor in employee retention and motivation. Aim: Determine the relationship between organizational commitment and intention to leave. Design:A descriptive correlational design was applied in this study. Setting: The study was conducted in all the units at Damanhour National Medical Institute. Sample: Study sample was 101 professional nurses. Tools: Two tools were used for data collection; Organizational commitment scale and intention to leave scale. Results:The results of the present study showed that nearly two thirds of professional nurses (62.3%) got moderate level of organizational commitment and above half of professional nurses (51.4%) had moderate level of intention to leave. Conclusion:  the present study concluded that there was significant negative correlation betweenaffective commitment, continuance commitment, normative commitment, and total organizational commitment with intention to leave. Recommendations: Therefore, it is recommended that,healthcare organization administrators should increase professional nurses' satisfaction through competitive salaries, encourage the team work spirit and conduct periodical meetings to discuss their problems to increase their commitment and eliminate their intention to leave.