Background: Thalassemia is the most common genetic disorder in Egypt, It is measured a fetal disease if proper chelation treatment is not established. The introduction of chelating agents able to removing extreme iron from the body has noticeably increased life expectancy time and improving the in general quality of life.
 the study aimed to identify the impact of an educational program about iron chelation therapy on the QoL for thalassemic children.Quasi-experimental research design was used , a convenient sample of 50 thalassemic children on chelation therapy, and their family caregiver at the pediatrics outpatient department at the Health Insurance Agency Hospital in Damietta city for 12 months from April 2015 to April 2016. The tools of data collection were an interview questionnaire for knowledge, and the pediatric QoL tool, child and parent versions. The resultsrevealed that there were statistically significant improvement of children's knowledge with P-value = 0.001. Subsequently, statistically significant improvement of children's quality of life at follow up compared with pre-intervention phase. The study recommended repetition of this research on large sample and in various places in Egypt and make the children with Thalassemia the focus of the health care team through designing several educational program and update posters and procures that improving their knowledge and then and then release improve in the quality of life of thalassemic children.