Background: Workers at textile factories are exposed to different hazards, which may have tremendous harmful effects on their health.         Aim: The aim of the study was to evaluate the relationship between occupational health hazards and the use of safety measures among workers in textile factory in Port Said city.       Materials and Methods: A cross sectional descriptive design was utilized to conduct this study. The study sample was carried on 100 workers in a textile factory in Port Said city. The data were collected using three tools: Structured Interviewing Questionnaire, an observational checklist and an environmental safety checklist.       Results: The results of this study showed that that more than three quarters (77%) of the study group was exposed to psychological hazards while about two thirds (64%) were exposed to physical hazards. Moreover, almost two-thirds (66%) of the study group didn't use different protective devices.         Conclusion: The study concluded that there was a highly significant difference between exposure of the studied group to various types of occupational health hazards and not wearing personal protective equipments (p ≤ 0.05).  It is recommended that the need for stressing on the application of International Standard Occupational Health and Safety Assessment Series in field work to improve occupational health and safety performance for the workers and  emphasizing on the importance and usefulness of personal protective equipment to be used in the right way.