Background: Liver transplantation has become the best treatment option for cirrhosis, acute liver failure and some tumors. This procedure has become routine with an excellent outcome in terms of both quality and length of survival.    Aim: The aim of the current study was to assess health related quality of life for patients with liver transplantation.     Materials and Methods: A descriptive exploratory design was used in this study. A convenience sample consisted of all available patients with liver transplantation at follow-up stage within 6 months at outpatients' of Gastroenterology Center at Mansoura University. Three tools were used for data collection.     Results: The present study concluded that liver transplantation surgery had affected Health Related Quality of life (HRQL) of the study subjects, the highest affected dimensions was for Role Limitation Due to Emotional Health and Social Well-Being, while the least affected dimension was for Role Limitation Due to Physical Health. There was no statistical significant relation between patients' socio-demographic characteristics and their HRQL, except residence and monthly income. There was a highly statistically significant relation between total knowledge of the study subject and their Role Limitation Due to Emotional Health dimension, while there were no statistically significant relation between other dimensions of quality of life and total knowledge score.     Recommendation: Continuous educational programs for patient with liver transplantation and their family about healthy life after liver transplantation, methods, complication and side effects of drugs and signs & symptoms of infection or rejection.