Background: Nurses are leaving their profession as a result of low levels of job satisfaction arising from their working conditions. Job satisfaction of staff nurses directly influences quality of care. Aim: the aim of the study was to study the correlation between the nurse's job satisfaction and quality of nursing care in Damietta Oncology Institute. Subject and Methods: A correlational descriptive study was used. Total sample included 45 nurses working in inpatient departments. Data were collected by using three different tools, job satisfaction questionnaire, chemotherapy administration observational checklist and pre- postoperative care observational checklists. Results: The results of the study revealed that the low level of job satisfaction among participating nurses was due to the lack of advancement and skills development, work environment safety, poor salaries and lack of responsibilities. Whereas, level of quality of nursing care showed was a moderate level. This performance was regarding preoperative nursing care and postoperative nursing care. Recommendation: these findings recommend establishing rules for promotion policies and salary scales for each of the different categories of nurses, develop training programs for nurses based on patients needs