Objectives: The aim of this study was to identify the factors leading to osteoporosis among menopausal women. Subject and Methods: The study was carried out in the rheumatic and rehabilitation outpatients' clinic at Mansoura University Hospital using a cross section analytical design.  The subjects of the study were 400 menopausal women attending the rheumatic and rehabilitation outpatients' clinic at Mansoura University Hospital setting and being diagnosed as positive or negative for osteoporosis.  Data were collected using three tools devised specifically for the study. Results: The results revealed that the osteoporosis was found in more than half of studied women (58.45%) of the women while, 41.15 % of women were not exposed to osteoporosis, the majority (93.7%) of the osteoporotic group had a history of chronic diseases compared to 77.3% of the control group. Conclusion: Many risk factors were associated with osteoporosis. Some of these factors were related to un-modifiable factors as (increases women age, associated medical conditions, family history of osteoporosis,….) , while the others were related to modifiable factors (abnormal body mass index in the form of overweight, morbid obesity, unhealthy dietary habits, unhealthy lifestyles,….) Recommendations: Early screening of menopausal women is recommended using DXA to help in the early detection of the disease, increasing women awareness about osteoporosis and its effect on women quality of life and upgrading their knowledge about the possible ways of its prevention and treatment.