Background:  Burnout remains a significant concern in nursing, affecting both nurses and patients. The stressful nature of nursing profession can lead to job dissatisfaction and burnout. Aim: This study is aimed to measure staff nurses' burnout, job satisfaction and their relation to patient satisfaction in Port Said hospitals. Design: A descriptive correlational research design was conducted in this study. Sample: The subjects of this study consisted of two groups: First group : nurses, they were (310) nurses from the selected hospitals. Second group: patients,  they were (116) patients from the selected hospitals. Tools: Data were collected using a questionnaire sheet containing three tools, first tool Maslach burnout inventory, second tool job satisfaction scale, and finally patient satisfaction questionnaire sheet. Results: The study results revealed that more than half of total nurses (59.52%) were burned out in both studied hospitals, nearly half of total nurses (43.49%) were dissatisfied with job in both studied hospitals. Conclusion:  There was a statistically significant negative correlation between total burnout, total job satisfaction, and patients' satisfaction levels at both of the studied hospitals. Recommendations: The study recommended to provide measures to reduce the workload on nurses and appropriate interventions should be conducted including their salary and improving work condition.