Background, inappropriate administration of inotropic medications can lead to devastating and harmful effects to critically ill patients and nurses have a great responsibility for administration of these medications, this study aimed to assess nurses' performance regarding administration of inotropic medications for critically ill patients. Design: A descriptive research design was used in the study. Setting: the present study was carried out at Critical Care Units affiliated to the Suez Canal University Hospital and General Hospital in Ismailia city. Sample:A convenient sample of all staff nurses (90 nurses) included the pilot study who were working at the previously mentioned settings. Tools of data collection: The data were collected using three tools (nurses' Knowledge Assessment Questionnaire, Nurses' observational checklist and Nurses' Attitude Questionnaire. Results: The majority of nurses had an unsatisfactory level of knowledge and the majority of studied nurses had unsatisfactory total practice with nearly most  of studied nurses had a positive attitude toward administering inotropic medications. Conclusion: there was a highly positive correlation between nurses' practice and nurses' knowledge and there was a positive correlation between the nurses' attitude and their knowledge and practice. Recommendations: Provide educational and training program and upgrading courses supported with evidence based practices and guidelines for appropriate administration of inotropic medications.