Background: It is imperative to know further about QOL in children to assess and improve the care that they receive. Quality of life varies from other forms of medical assessments in that it emphases on the people's own opinions of their welfare and other features of life. Aim of study: Assess the quality of life among children with beta-thalassemia. Design: A descriptive research design was utilized in this study. Setting: the study was carried out at the outpatient hematology clinic at Mansoura University children's hospital in Dakahlia governorate. Sample: the study  sample  was  collected from 124 children with beta thalassemia major. Results: Almost all the studied children who complied with blood transfusion had low QOL. Also, the majority compliant with chelation therapy had lowQOL. The studied thalassemic children experienced moderate QOL related to physical, emotional, and school functioning and experienced high QOL regarding social functioning. Conclusion: the highest percentage of the studied children had moderate levels of QOL. There was a statistically significant association between children's QOL and their knowledge. Moreover, there was a positive relation between children's ages and their total scores of QOL. Recommendation: regularand continuous health education programs are essential for children suffering  from beta thalassemia and their mothers.