Back Ground: Technology creates challenges for nurses and nursing care and may dehumanize the caring of the patients. A Quasi-experimental design was used to evaluate the impact of applying guidelines on nurses' perception regarding positive aspect of using technological devices in critical care units. It was conducted in critical care units of Port-Said General Hospital, El- Zohoor Hospital, Port-Foad Hospital, El-Mabarrah Hospital (Health insurance) and El-Tadamon Hospital. The study samples consisted of 112 nurses working in the previous settings. The data were collected through a structured questionnaire to assess nurses` perception about positive aspects of using technological devices in critical care units. The results revealed that the nurses' perception regarding the positive aspects in related to nursing care increased from 42.9% in pre-intervention to 95.5% in post-intervention and 83.9% through the follow up with high statistically significant relation as p=0.000. In multivariate analysis, the model explains 17% of the change in nurse's perception in related to positive aspects after intervention. It could conclude that, educational guidelines would be benefits. The study recommended different strategies for nursing practice to enhance nurses` perception regarding use of technological devices in critical care such as handout with Arabic language including comprehensive information about all aspects of technologies.