Background: Systemic lupus erythematosus (SLE) is an autoimmune, rheumatic disease, potentially affecting most organ systems. The disease is commonly considered to be chronic and occurs in often unpredictable flares, with alternating low and high disease activity. Good self-management is essential to managing lupus; as individuals with SLE can improve their prognosis by learning about many aspects of the illness as well as closely monitoring their own health with their care providers. Aim of the study: This study aims to evaluate the effect of Self-Management Guidelines on Awareness, health outcome and Self-Efficacy for Patients with Systemic Lupus Erythematosus in Mansoura University Hospital. Study design: A quasi-experimental design was utilized to accomplish the aim of this study. Setting: The study was conducted at the medical department inpatients and medical clinics outpatients at Mansoura University Hospital. Subject: A convenient sample of all available patients admitted to the medical department inpatients and medical clinics outpatients at Mansoura University Hospital within 6 months which reached to 65 patients from September 2015 to February 2016. Tool of data collection: Health assessment Questionnaire, Self-Efficacy Scale and Lupus Awareness's Quiz. Results: there were high statistically significant difference regarding severe pain, generalized health status and level of awareness (P<0.001) post implementation of self-management guidelines. The study concluded that: The systemic Lupus Erythematosus self-management guidelines had positive effects on the patients in reducing disability, improving self-efficacy and patient awareness. The study recommended that: Further researches about self-management of patients with SLE are highly recommended to reach the peak level of health satisfaction among those patients