Background: The risks associated with the delivery of healthcare services are increased in Intensive Care Units (ICUs). The aim of this study was to develop a manual for safety measures in Intensive Care Units (ICUs) in selected hospitals at Port Said city. This methodologicalstudy involved 48 experts for validation of the manual, which was developed by the researcher based on assessment findings. The data collection tools included an opinionnaire for jury.  The manual was validated through experts' opinions. The manual is valid by high percentages of jury agreement upon its face and content validity, reaching unanimous agreement in many of the items. The study recommends use of the developed manual in ICUs, with close supervision, and a system of rewards and punishment. The hospital administration must establish patient safety as a priority in its mission, and provide all needed equipment and supplies. Training courses in patient safety are strongly recommended. Further research is suggested to assess the impact of the use of the developed manual on nurses' performance of patient safety measures.